There is no one-size-fits-all answer to this question, as the best way to secure your MongoDB database from hackers may vary depending on your specific setup and security needs. However, some general tips to help secure your MongoDB database include:

1. Use a strong password for your MongoDB user account.

2. Enable authentication for your MongoDB database.

3. Restrict access to your MongoDB database using firewalls or other network security measures.

4. Keep your MongoDB database and software up to date with the latest security patches.

5. Perform regular backups of your MongoDB database.